LoveFilm's summary of the plot of the film Southern Comfort:

Robert Eads is a female-to-male transsexual suffering from ovarian cancer who faces sure death after 20 doctors have refused to treat him for his condition. Far away from Atlanta's city lights, Robert makes a life for himself and his family—his two families: his biological family of two parents, two sons by birth, and a darling three-year-old grandson; and his chosen family of two female-to-male transsexual sons, Maxwell and Cass. Robert is falling in love with Lola Cola, a sultry male-to-female transsexual, but as hard as he tries to resist, in the face of his impending death, the romance blooms beautifully in bittersweet irony.

Sounds like an interesting film. It isn't the Southern Comfort they mean, though. That is a very different film...